For the Marburg Virus to infect the host's cell an essential element is needed. For Marburg and Ebola that element is the
Niemann–Pick C1 (NPC1) membrane protein (1). This protein mediates infection by binding to the viral envelope glycoprotein. Once the Marburg virion attaches, the virion envelop fuses with the cellar membrane and then the nucleocapsid is released into the cytosol. The RNA-dependent RNA polymerase transcribes
genes into positive-stranded mRNAs, which are later translated into structural and other proteins. The RNA of the virion is then integrated with the host cell's DNA and transcribed and translated to create more virion RNA. Once all of the elements required to create a new Marburg virion the virus exits the cell via exocytosis and is then able to infect more of the host's cells.
Sources:
1. Bhattacharya, Arin. A Review of Hemorrhagic Fever. JACK, 2014. Print.
2. http://classroom.sdmesa.edu/eschmid/lecture9-microbio.htm
3. http://www.cdc.gov/vhf/marburg/transmission/index.html
Image: http://en.wikipedia.org/wiki/NPC1
1. Bhattacharya, Arin. A Review of Hemorrhagic Fever. JACK, 2014. Print.
2. http://classroom.sdmesa.edu/eschmid/lecture9-microbio.htm
3. http://www.cdc.gov/vhf/marburg/transmission/index.html
Image: http://en.wikipedia.org/wiki/NPC1